Prescient Therapeutics granted U.S. Patents

THE ROADHOUSE PHARMACY: Prescient Therapeutics (ASX: PTX) has had two additional patents granted by the U.S Patent and Trademark Office.

The company said the patents are important in the development and commercialisation of its drug candidate PTX-200.

The first patent provides broad protection for the company’s novel method of treating chemotherapy resistant ovarian cancer with the AKT inhibitor compound PTX-200, formerly known as TCN-P or triciribine phosphate monohydrate.

The second patent provides broad coverage for treating various cancer types including breast cancer by administering PTX-200 in combination with trastuzumab.

“These U.S. patents further enhance our intellectual property portfolio,” Prescient Therapeutics managing director Dr Robert Crombie said in the company’s announcement to the Australian Securities Exchange.

“They confirm our monopoly rights on this novel and highly encouraging compound which we believe has significant potential to improve the clinical outcome for women with chemotherapy-resistant ovarian cancer.

“Prescient’s drug candidate PTX-200 is being trialled in patients who have become resistant to platinum-based drugs as it inhibits the AKT tumor survival pathway associated with platinum drug resistance PTX-200, in combination with standard of care drug carboplatin, is currently in Phase 1b/2 trial as a new therapy for ovarian cancer, the fifth leading cause of cancer death in women in the United States.

“Currently approximately half of the patients diagnosed with ovarian cancer will die from metastatic disease as they become resistant to the platinum-based drugs that constitute front line therapy.

“Prescient’s drug candidate PTX-200 is aiming to minimise this resistance.”

Website: www.prescienttherapeutics.com

Cynata claims stem cell world first

THE ROADHOUSE PHARMACY: Cynata Therapeutics (ASX: CYP) has claimed a world first breakthrough in the manufacture of stem cells and is now set to scale up manufacturing of mesenchymal stem cells (MSCs) for therapeutic use.

The company’s lead platform technology is a new stem cell manufacturing process known as Cymerus, which Cynata says has just been validated at a biomanufacturing site in the United States.

According to Cynata, trials carried out at Waisman Biomanufacturing in Madison, Wisconsin have now confirmed the company’s state-of-the-art stem cell manufacturing process is capable of producing MSCs for therapeutic application, consistently, efficiently and economically, in a Good Manufacturing Practice (GMP) production environment.

The important factor to come out of the trials is that the Cymerus process uses, what the company described as being an effectively limitless starting material – a bank of induced pluripotent stem cells (iPSCs) – and a patent-protected process to derive MSCs for commercial use.

This, Cynata claims, is a world-first breakthrough that sets Cymerus apart from all existing methods of MSC production, which require a continuous supply of new tissue donations.

Cynata expects to be able to produce all of the MSCs it will ever need from a single iPSC bank, derived from a single blood donation.

This means there will be no need to repeatedly source, screen, and test new donors and issues with donor-to-donor variability will not arise.

A Phase I human clinical trial of the Cymerus stem cell technology is currently in planning stage, with discussions underway with regulatory authorities to ascertain and clarify the likely regulatory path for the product.

“An equity research report compiled last year by respected biotech analyst Stuart
Roberts saliently noted that should Cynata demonstrate an ability to make cells at industrial scale under GMP then it would be in a position to be a ‘genuine Stem Cell Revolutionary’,” Cynata Therapeutics chief executive officer Dr Ross Macdonald said in the company’s announcement to the Australian Securities Exchange.

“We have just achieved this important goal.

“Our novel method of manufacturing stem cells – the Cymerus technology – allows for virtually unlimited quantities of MSCs of consistent quality to be manufactured for therapeutic use.

“We look forward to aggressively pursuing commercial applications for this game changing therapeutic technology.”

Macdonald went on to say that one of the big issues facing regenerative medicine companies was how to produce enough stem cells consistently, reproducibly and economically for clinical and commercial benefit.

“Our international manufacturing partner has now confirmed our proprietary process can achieve this in a GMP manufacturing environment,” he continued.

“This is a key requirement for pharmaceutical companies as they move to capture the opportunities presented by stem cell medicine.

“An abundance of stem cells clears a path toward low cost, cutting edge cell therapy.”

Email: admin@cynata.com

Website: www.cynata.com

Richard Shemesian – Apollo Minerals

ONE OFF THE WOOD: Apollo Minerals (ASX: AON) has acquired a 70 per cent interest in the Orpheus base metals JV project with Enterprise Metals (ASX: ENT) in the Fraser Range minerals province in Western Australia with the intention to explore for major nickel and base metal deposits in the project area.

The project area consists of four tenements covering 600 square kilometres where Enterprise has identified four priority exploration target areas: at the Plato, Heart, Highway and McPhersons prospects. Other highly ranked anomalies exist and remain untested at this stage.

 

Apollo Minerals chairman Richard Shemesian dropped by The Roadhouse to provide some details on the project.
 
Richard, Apollo, by way of its JV with Enterprise Metals is about to take up residence in the hottest exploration address in the country, a couple of doors down from Sirius Resources (ASX: SIR) in the Fraser Range of Western Australia.

It is exciting. Apollo has been looking for an opportunity just like Orpheus to come up in this area for quite some time, but that belt, especially the high gravity zone, is already highly-populated and tightly-held.

Apollo is looking forward to moving in and progressing exploration to unveil value from the properties.

It’s all well and good to find an ‘in’ to the Fraser Range, but it is also important to have found the right project?

That’s right. We looked at a lot of projects in the area, but we wanted to be in the Main Zone, that is the belt containing the high density rocks, which is the most prospective.

We have kept an eye on the area, and obviously it was very hot after Sirius announced its Nova discovery in 2012 and subsequently Bollinger in 2013. The area has a lot to offer.

Since then, of course, the market has been difficult so the region has been on a simmer, but we feel our timing has been impeccable in terms of the action that is currently happening out there.

It’s our understanding that private groups are spending big amounts – rumoured to be around $1 million a month – and Sirius is now carrying out quite a lot of drilling down at its Crux prospect.

The Orpheus prospect is situated directly between Sirius’ Nova deposit and Crux so we will be taking keen interest in the results from there, because if they make any sort of discovery at Crux it will also be a great result for us.

The Sirius fairy-tale of hitting the big time with perceived little effort has placed a bit of expectation on companies who are also in the area, with investors expecting similar results?

There is no doubt Sirius has provided investors a lot of excitement in relation to the area, but we understand it is going to take a lot of money and a lot of hard work and expertise to find these deeper ore bodies.

You have to be in the right area and that’s one we have ticked off. Then you have to go out and do the work and then you need to have people with the right expertise.

The advantage we have is the make-up of our Board, which includes people like Eric Finlayson a former head of Rio Tinto exploration world-wide.

Eric is a representative of HPX which is an exploration group indirectly controlled by Robert Friedland.

Apollo is also involved in the Commonwealth Hill IOCG Joint Venture project in the Gawler Craton with High Power Exploration (HPX) to explore for IOCG deposits.

Under the JV HPX will provide state of the art technologies and expertise to explore for IOCG’s across Apollo’s 100 per cent-held tenements.

HPX has made an initial equity investment in AON. Under the JV, HPX has the right to earn 80 per cent via payment of $3.4 million in two phases.

Your exploration activities aren’t just focused on the Fraser Range, you’re also still very busy with your South Australian projects. There are probably a lot less companies doing as much work on the ground than Apollo at present?

We have received a lot of market recognition and support from HPX and Robert Friedland by declaring our exploration focus is to find large deposits.

This is where the interest lies in discovering IOCG -type deposits in the world-class, top tier terrains – Olympic Dam is in that category.

HPX is looking for that type of target, which is why we are working together in South Australia to find that IOCG discovery.

The Gawler Craton is the sort of territory you are likely to find such a deposit – they’re not easy to find, you need a serious amount of cash, hard work and perseverance.

Is that what you’re hoping to find in the Fraser Range?

We have seen world-class nickel projects emerge in the Fraser Range and that is what we looking for, rather than a small project the market would not be interested in. We really want to develop a major project.

That’s another aspect that distinguishes us from other explorers. It’s easy to say a company is exploring, but what are they actually exploring for?

I hope we have made it clear in our announcements to the market that we’re not looking for small things – we are looking for world-class projects.

What was it about the Orpheus project that raised the flag for Apollo?

Firstly, it is in the right geological setting – in the Fraser Range Mafic Complex – our experts are of the opinion this area is where there are going to be more massive sulphide nickel discoveries.

Secondly the acquisition of quality data set.  Enterprise Metals has already spent over $2.5 million on exploration and just on 4,000 metres of drilling, from which they have identified nickel and copper anomalies at surface, and have also had success in hitting nickel sulphides. Apollo has had similar results in South Australia but not to the same extent.  The exploration coverage and targets identified provide a platform to launch exploration with more drill testing of priority target areas.

I don’t think the market has given Enterprise the credit they deserve, however I think what Enterprise has realised is that it is better to Joint Venture these projects with companies that have funding and strong partners.

What the Analysts Say

WHAT THE ANALYSTS SAY: Interesting news and views from across the Resource Analyst universe.

Website: www.beerandco.com.au

Company: Pilbara Minerals (PLS.ASX)

Pilbara Minerals acquired a 50 per cent stake in the Tabba Tabba project in October 2013.

PLS published a feasibility study on Tabba Tabba in February 2014 and has since raised equity to bring it into production.

In May 2014, PLS announced the acquisition of 100 per cent of Pilgangoora, 55 kilometres from Tabba Tabba in the Pilbara region.

Tabba Tabba Resource upgrade

On 19 January 2015, PLS announced an upgraded resource, from 213,000 tonnes containing 572,200 pounds of tantalum, to 318,000 tonnes containing 666,200 pounds.

Of the 94,000 pound increase, 73,000 pounds was in the Measured category.

The increased volume of Resources is due to drilling in areas that need to be mined for access to the pit.

These areas were lower grades than Beer & Co’s earlier estimates.

Tabba Tabba works approval delayed

PLS has been required to do some more work to get approval to begin work on‐site.

These approvals are now expected in March. The plant is ready to be installed when the pads are prepared.

Greater upside at Pilgangoora

PLS had completed 4,812 metres of a 10,000 metre drilling program at Pilgangoora.

Drilling is expected to re‐start soon. The program is expected to result in an upgrade and extension of Resources.

Website: www.breakawayresearch.com

Company:   Avalon Minerals Limited (ASX: AVI)

Avalon is an ASX-listed minerals developer with its key project being the Viscaria copper-iron project in the Kiruna mining district of northern Sweden.

The project has sufficient resources to subsequently upgrade this to a longer term, high throughput copper/iron operation with appreciable blue sky.

We see potential resource additions coming from expansions to the known mineralisation and the good chance for regional exploration success.

The company is working towards development of the project, with a DFS expected to be completed by late 2016, and first production, of between 10,000 tonnes per annum and 15,000 tonnes per annum of copper in 2018, potentially to coincide with forecast improvements in copper prices.

In addition to the core project, which is comprised of four mineralised zones, a number of district and regional exploration licences are held, with these having excellent prospectivity, as evidenced by historic drill results that have not been followed up.

In response to current market conditions and commodities prices, Avalon Minerals options for a staged development of its Viscaria project, as an alternative to the scenario presented in the 2014 Scoping Study.

The proposed operation includes a first stage, relatively low capex high-grade copper only operation, with a later expansion to a larger copper and magnetite operation.

Planned operations include both open cut and underground mines, with exploitation concessions now granted over all of the three start-up zones.

The company envisages an initial 5 year, approx. one million tonnes per annum operation, with capex in the order of US$100 million, expanded to a 2.5 million tonnes per annum to 3.5 million tonnes per annum operation from year six which will require an estimated extra US$130 million in capex, which includes the magnetic separation plant.

There is also potential for a copper oxide circuit to be included, to treat shallow high grade oxide ores.


Disclaimer: The above is intended as a guide only. The Roadhouse accepts no responsibility for investments made from this advice, successful or otherwise.

The views, opinions or recommendations of this article do not in any way reflect the views, opinions, recommendations, of The Resources Roadhouse.

The Roadhouse makes no representation or warranty with respect to the accuracy, completeness or currency of the content. The content is for educational purposes only and does not constitute financial advice. Independent advice should be obtained from an Australian financial services licensee before making investment decisions.

RIU Exploers to kick of 2015 Conference Season news

THE CONFERENCE CALLER: As far as investors are concerned nothing
beats the opportunity of actually meeting the people in charge of the
company that could be your potential investment vehicle.

The RIU Explorers Conference in Fremantle is
celebrating its 14th year of providing that opportunity of bringing mining company executives and
investors together.

The RIU Explorers Conference has long been part of the Resources Industry landscape.

The conference was first held in February 2002, at a time not totally
dissimilar to the one we are currently experiencing, when the resources
industry was just starting to pull out of a long period of malaise.

The 250 delegates there witnessed the first signs of recovery and many
junior stocks got their first kick in investment that led to some of
them becoming strong mid to high cap stocks.

At the same time many in the supply industry used this event as a
springboard to the growth that set themselves for many years of strong
profits.

A lot of water has flowed under the bridge since then with Australia.
Along with the rest of the world swimming through the resources boom,
then wading through the mire of the GFC, which has been followed by a
dried up lake of investment.

Over the past year, however, we have just started to see a return to
investment in resources stocks that will hopefully lead to better times
in the next six to 12 months.

Through all of this the RIU Explorers Conference has grown to an event
which fills the Esplanade Hotel Fremantle by Rydges with 50 Exhibition
booths and has regularly attracted between 700 and 800 delegates.

It is the event that starts the Australian Resources Conference Calendar
and is always the most optimistic and eagerly awaited event.

As always the two day event will feature CEO’s, as well as Operations
and Exploration Managers of the best mining and exploration companies
plus new emerging explorers.

All this will provide delegates with an event to garner investment and
to meet with other resources industry professionals to discuss new
options and progress their business.

RIU Conferences invites you to attend and network, get informed, and invest at the 2015 Explorers Conference.

Carnarvon completes Thai Asset divestment

THE ROADHOUSE BOWSER: Carnarvon Petroleum (ASX: CVN) announced it has completed the divestment of the company’s remaining 20 per cent interest in the Thailand oil production concessions L44/43, L33/43 and SW1A.

The company flagged the divestment in December 2014 saying it had agreed to sell its remaining 20 per cent interest in its Thai assets to the Berlanga Group for a base consideration of US$50 million plus final completion adjustments.

In addition, Carnarvon retains its US$32 million receivable in the Thai assets, which was agreed to as part of the Loyz transaction the company announced in March 2014.

“We are pleased to have completed another important step in transitioning the company into a well-funded and well-resourced North West Shelf focused business,” Carnarvon Petroleum managing director and chief executive officer Adrian Cook said in the company’s announcement to the Australian Securities Exchange.

“Carnarvon now has the cash to ensure it can add value in the Phoenix area through further exploration and appraisal activities, fund ongoing corporate costs through the US$32 million receivable linked to Thailand oil field revenue and grow the business through further exploration activities, such as those relating to its 100 per cent-held Cerberus blocks in the Carnarvon Basin.”

Elixir completes Petra project seismic

THE ROADHOUSE BOWSER: Elixir Petroleum (ASX: EXR) announced the acquisition of a proprietary 2D seismic survey on the company’s Petra project, located in Washington County, Colorado USA.

The company said approximately 35 kilometres of seismic acquisition was completed with no incidents, on time and within budget.

Based on quality assurance undertaken during the shooting of the survey, Elixir said it considers the data quality to be very good, adding conditions for the acquisition were ideal, with winter conditions providing a good seismic response.

Elixir indicated the data is currently being processed and integration of the new data into the company’s data set will be completed mid to late March 2015.

The company anticipates the detailed interpretation of the new data together with the existing data set will further enhance its understanding of the structures in this core area of the Petra project.

“The seismic shoot was undertaken without a hitch by our Denver based partner and further adds to their already proven operating capability,” Elixir Petroleum managing director Dougal Ferguson said in the company’s announcement to the Australian Securities Exchange.

“We eagerly await the integration and interpretation of the full data set which will allow both Elixir and Apollo to determine the next stage of the exploration program.

“The completion of this survey is yet another milestone we have accomplished in less than six months from the initial acquisition of the Petra project.”

Email: info@elixirpetroleum.com

Website: www.elixirpetroleum.com

Immuron signs agreement to sell Travelan in China

THE ROADHOUSE PHARMACY: Immuron Limited (ASX: IMC) has entered into an agreement with Linker Holdings Limited, a Beijing company with offices in Hong Kong, for the sale of Travelan in the Peoples’ Republic of China, Hong Kong and Macau.

Under the agreement, Linker will have the exclusive rights to market, distribute and sell Travelan as a functional food and a dietary supplement in its licensed territory and has undertaken to contractually comply with specified annual minimum purchase obligations.

Immuron said Linker’s minimum purchase obligations represent a notable increase in the volume of the company’s Travelan business and will be measurable in multiples of the company’s current volumes, adding that the Chinese market has the potential to eclipse the combined global sales of Travelan in all other regions.

The company talked up the scale of the opportunity the deal presents, indicating the success many products marketed in China experience, often being transformative for the originator company.

Immuron said the commencement of this increase in Travelan sales is expected to occur as soon as Linker attains regulatory approval from the Chinese Food and Drug Administration (CFDA).

“Travelan is currently available in Australia and Canada,” Immuron chairman Dr Roger Aston said in the company’s announcement to the Australian Securities Exchange.

“China represents a very large market opportunity for the expansion of our global Travelan franchise.

“China is a large and increasingly wealthy market, in which gut and liver health are important concerns.

“Additionally, the South East Asian cultures’ pre-disposition to, and appreciation of, the benefits of colostrum strongly positions Travelan in this market.

“Linker has a team with a proven record of successfully commercialising a range of products, which gives us great confidence on the potential of Travelan in the Chinese market and we expect that the strength of this market combined with minimum purchase order requirements will result in substantial growth in Immuron’s revenue over the coming two-to-three years.”

 

Website: www.immuron.com

RIU Explorers to kick off 2015 Conference season in Fremantle

THE CONFERENCE CALLER: As far as investors are concerned nothing beats the opportunity of actually meeting the people in charge of the company that could be your potential investment vehicle.

The RIU Explorers Conference in Fremantle is
celebrating its 14th year of providing that opportunity of bringing mining company executives and
investors together.

The RIU Explorers Conference has long been part of the Resources Industry landscape.

The conference was first held in February 2002, at a time not totally
dissimilar to the one we are currently experiencing, when the resources
industry was just starting to pull out of a long period of malaise.

The 250 delegates there witnessed the first signs of recovery and many
junior stocks got their first kick in investment that led to some of
them becoming strong mid to high cap stocks.

At the same time many in the supply industry used this event as a
springboard to the growth that set themselves for many years of strong
profits.

A lot of water has flowed under the bridge since then with Australia.
Along with the rest of the world swimming through the resources boom,
then wading through the mire of the GFC, which has been followed by a
dried up lake of investment.

Over the past year, however, we have just started to see a return to
investment in resources stocks that will hopefully lead to better times
in the next six to 12 months.

Through all of this the RIU Explorers Conference has grown to an event
which fills the Esplanade Hotel Fremantle by Rydges with 50 Exhibition
booths and has regularly attracted between 700 and 800 delegates.

It is the event that starts the Australian Resources Conference Calendar
and is always the most optimistic and eagerly awaited event.

As always the two day event will feature CEO’s, as well as Operations
and Exploration Managers of the best mining and exploration companies
plus new emerging explorers.

All this will provide delegates with an event to garner investment and
to meet with other resources industry professionals to discuss new
options and progress their business.

RIU Conferences invites you to attend and network, get informed, and invest at the 2015 Explorers Conference.

 

THE INSIDE STORY

CORAZON MINING TAKES VICTORY AT LYNNE LAKE


 

Corazon Mining (ASX: CZN) has recently taken advantage of such an opportunity by finalising terms for the acquisition of the Victory nickel project in the Lynn Lake nickel-copper field, in the province of Manitoba – Canada’s third largest nickel producing region, from TSX-listed Victory Nickel.


LATEST NEWS FROM PARTICIPATING COMPANIES

RAMELIUS RESOURCES LOCKS IN FORWARD GOLD SALES

THE BOURSE WHISPERER: Ramelius Resources (ASX: RMS) has sold forward 47,200 ounces of gold at an average price of $1,582 per ounce.

POSEIDON INDENTIFES NEW LAKE JOHNSTON MINERALISED ZONE

THE DRILL SERGEANT: Poseidon Nickel (ASX: POS) has received assays for 29 underground diamond drill holes undertaken at the company’s Lake Johnston project, prior to its acquisition.

PLD RAISES POTENTIAL FOR ADDITIONAL RESOURCES AT ADMIRAL BAY

THE DRILL SERGEANT: PLD Corporation (ASX: PLD) has released an Exploration Target Range (ETR) at the company’s Admiral Bay zinc project in the northwest of Western Australia.

ROX RESOURCES RECIEVES POSITIVE SCOPING STUDY RESULTS

THE BOURSE WHISPERER: Rox Resources (ASX: RXL) has received the results of a Scoping Study undertaken on the company’s Fisher East nickel project, located north-east of Leinster in Western Australia.

TALISMAN MINING ENCOURAGED BY EARLY RESULTS AT SINCLAIR NICKEL MINE

THE DRILL SERGEANT: Talisman Mining (ASX: TLM) has provided an update to
recent activities carried out at the company’s Sinclair nickel project
in Western Australia.

NORTHERN STAR INCREASES RESOOURCES AND RESERVES AT JUNDEE AND PAGASUS

THE DRILL SERGEANT: Northern Star Resources (ASX: NST) has increased
Resources and Reserves at the company’s Jundee gold mine in Western
Australia

PIONEER RESOURCES COMPLETES RAISING, ANNOUNCES SPP

THE BOURSE WHISPERER: Pioneer Resources (ASX: PIO) has completed a
capital raising of $500,004 to help fund ongoing field programs at the
company’s exploration projects in Western Australia. 

CRAIG OLIVER AWARD

A highlight of the Explorers Conference each year is the presentation of the Craig Oliver Award.

This award is presented in memory of Craig Oliver who passed away on Saturday 19th June 2010, aged 46.

Oliver was on the Sundance Resources plane which tragically crashed in the Congo with the loss of all people on board.

2015 Nominees are:

Cassini Resources (ASX: CZI)
Doray Minerals (ASX: DRM)
Gindalbie Metals (ASX: GBG)
Metals X (ASX: MLX)
Northern Star Resources (ASX: NST)
OceanaGold Corporation (ASX: OGC)
Orbis Gold (ASX: OBS)
Renaissance Minerals (ASX: RNS)


 DON’T MISS YOUR OPPORTUNITY TO ATTEND THESE UPCOMING CONFERENCES

 

 

 

 

Pioneer Resources completes raising, announces SPP

THE BOURSE WHISPERER: Pioneer Resources (ASX: PIO) has completed a capital raising of $500,004 to help fund ongoing field programs at the company’s exploration projects in Western Australia.

The capital raising was via a placement of approximately 27.78 million fully paid ordinary new shares at an issue price of 1.8 cents per share, to professional and sophisticated investors and clients of Bell Potter Securities.

Pioneer subsequently announced a Share Purchase Plan to raise up to a further $750,000.

Under the SPP, existing eligible shareholders can apply for up to $15,000 worth of new shares in the company at the same issue price as the placement; 1.8 cents per each.

The company explained the funds will be initially allocated to the Fairwater nickel project in the Albany-Fraser Orogen, and for near-mine drilling at the Blair nickel mine extensions project.

“We are delighted with the response from new investors to the company’s share placement, which we see as strong validation for our ongoing, targeted exploration programs,” Pioneer Resources managing director David Crook said in the company’s announcement to the Australian Securities Exchange.

“We are also pleased to offer the Share Purchase Plan to existing eligible shareholders on the same terms as the placement, providing the opportunity to increase share holdings in the company as it enters a very active exploration phase.

“The timing of these capital raisings follow the receipt of the final approvals needed to commence ground disturbing work programs at the company’s exciting Fairwater nickel project.

“The POW assessment was approved on 6 February 2015, and immediately an EM crew commenced work.”

Email: dcrook@pioresources.com.au

Website: www.pioneeresouorces.com.au